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Prior plant studies support the plausibility of this approach where stress combined with epigenetic perturbation has been shown to increase extrachromosomal retrotransposon DNA and mobilization outputs, and long-read eccDNA profiling under epigenetic stress has revealed dramatic, family-specific bursts of eccDNA production (Thieme et al., 2017

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However, this effect can also lead to gastrointestinal adverse effects, including nausea, vomiting, diarrhoea, and constipation , which are among the most commonly reported side effects